Patient question
My knee got hot and swollen a few days after an injection. Is it infected?
Quick answer
It may be a flare, a short reaction to the injection that usually starts within 24 to 48 hours and settles in a few days. Infection is rare but serious: pain that keeps worsening after day two, increasing heat and swelling, or fever needs same-day assessment, advises Doha knee surgeon Dr. Pablo Gelber at Aman Hospital.
Post-injection flare
- Usually begins within hours to two days of a steroid, hyaluronic acid or PRP injection
- Aching, warmth and some swelling
- Peaks early, then improves day by day
- No fever, and you feel well otherwise
- Eases with rest, ice and simple painkillers
PRP in particular often causes soreness for a few days, which is expected.
Signs that suggest infection
- Pain that keeps getting worse after the second or third day instead of easing
- The knee becomes hotter, redder and more swollen
- You cannot bend it or bear weight
- Fever, chills, sweats or feeling unwell
- Redness spreading up or down the leg, or pus at the injection site
Infection after a knee injection is uncommon when sterile technique is used, but it can happen days to a couple of weeks later. Diabetes, steroids and a weak immune system make it more likely and may hide fever.
What to do
If symptoms fit a flare and are improving, rest, ice for 15 to 20 minutes several times a day and take simple painkillers. Call the clinic that gave the injection if you are unsure. If any infection sign appears, go to an emergency department the same day and tell them which injection you had and when. Do not start antibiotics at home, as fluid from the knee is usually tested first.
Follow-up in Doha
If Dr. Gelber gave your injection at Aman Hospital, contact his team as soon as you are worried. When infection is suspected, the knee is aspirated and the fluid tested. If confirmed, treatment is urgent: antibiotics into a vein and, in most cases, a keyhole washout of the joint.
Frequently asked questions
Does a steroid injection hide an infection?
Steroid can reduce the redness and fever that normally signal infection, which is why worsening pain after a steroid injection should be taken seriously.
Can I have another injection after a flare?
Often yes, after the flare settles and infection has been excluded. Your doctor may change the type of injection or the technique.
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